Serum Ca > 10.3 mg/dL |
↓ |
Order intact PTH |
Low PTH |
High PTH |
↓ |
↓ |
Order Parathyroid Hormone-Related Peptide (PTHrP) |
Primary hyper-parathyroidism or Familial benign hypercalcemia |
↓ |
↓ |
|
High PTHrP is suggestive of cancer |
Low/normal PTHrP ↓ order Vitamin D |
order urinary calcium |
|
↓ |
↓ |
↓ |
|
Low ↓ suggestive of cancer |
High ↓ suggestive of lymphoma or granulomatous disease |
High ↓ Primary hyper-parathyroidism |
low ↓ Familial benign hypercalcemia |
If low corrected calcium: determine intact Parathyroid hormone (PTH), creatinine (Cr), phosphorus (P) and Magnesium (Mg).
Serum calcium < 8.2 mg/dL |
↓ |
Order serum albumin |
↓ |
↓ |
If < 4.0 g/dL |
If > 4.0 g/dL |
Use corrected Ca |
Use result value |
↓ |
Use result value |
If still < 8.2 mg/dL |
If result became normal |
Order intact Parathyroid hormone (PTH) creatinine (Cr) phosphorus (P) Magnesium (Mg) |
↓ hypoalbuminemia |
↓ |
↓ |
↓ |
↓ |
↓ |
|
Low PTH normal Cr normal/high P normal Mg |
Low PTH normal Cr normal/high P low Mg |
Normal PTH normal Cr normal/low P normal Mg low albumin |
High PTH normal Cr Normal/low P normal Mg |
High PTH high Cr normal/high P normal Mg |
|
↓ |
↓ |
↓ |
↓ |
↓ |
|
Hypo-parathyroidism |
Magnesium deficiency |
Hypo-albuminemia |
check vitamin D deficiency |
Renal Disease Or pseudo-hypo-parathyroidism |
|